Tartrate-Resistant Acid Phosphatase

One of several acid phosphatases in humans, other mammals, plants, and a few prokaryotes. The protein fold of tartrate-resistant acid phosphatase (TRAP) resembles that of the catalytic domain of plant purple acid phosphatase and other serine/threonine-protein phosphatases that also contain a metallophosphoesterase domain. One gene produces the various forms which include purple acid phosphatases from spleen and other tissues. Tartrate-resistant acid phosphatase is a biomarker for pathological states in which it is over-expressed. Such conditions include GAUCHER DISEASE; HODGKIN DISEASE; BONE RESORPTION; and NEOPLASM METASTASIS.

Also Known As:

AcPase V; Acid Phosphatase V; TRAP Type 5 AcPase; TRAcP; Tartrate-Resistant Acid Phosphatase Type 5; Type 5 Acid Phosphatase; Uteroferrin; Acid Phosphatase, Tartrate-Resistant; Phosphatase V, Acid; Phosphatase, Tartrate-Resistant Acid; Tartrate Resistant Acid Phosphatase; Tartrate Resistant Acid Phosphatase Type 5; V, AcPase; V, Acid Phosphatase

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Hydrolases: 2206
    - Esterases: 1594
      - Phosphoric Monoester Hydrolases: 7607
        Acid Phosphatase: 2357
        Tartrate-Resistant Acid Phosphatase: 1249
        Phosphoprotein Phosphatases: 1228
        Tartrate-Resistant Acid Phosphatase: 1249
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Intracellular Signaling Peptides and Proteins: 32
    - Phosphoprotein Phosphatases: 1228
      - Tartrate-Resistant Acid Phosphatase: 1249

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Disease

Drug/Important Bio-Agent (IBA)